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The effects of IGF-1 on muscle cells are three-fold

GunasekaranMKViranaickenWGirardA-CFestyFCesariMRocheRet alInflammation triggers high mobility group box 1 (HMGB1) secretion in adipose tissue, a potential link to obesity

In contrast to developing NP cells, mature NP cells are described as chondrocyte-like, are smaller (10 m diameter), and do not contain intracellular vacuoles (Hunter et al., 2003)

Each of these demanding perquisites and especially their combination challenge the development of suitable boron delivery agents, limiting the establishment of BNCT as a viable cancer treatment modality in the clinic so far (Kreiner et al., 2016)