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It is a heterogeneous group, as different can be the causes of the better adaptation of a cell to hypoxia, but the common factor is that cells more equipped to survive in hypoxia, are more likely to remain vital and able to growth after treatment-induced reduction of the vascularity

NCEP-NCAR reanalysis and ERSST data were provided by the NOAA/OAR/ESRL PSD, Boulder, Colorado, USA, from their Web site at Ethics declarations Competing interests The authors declare no competing interests

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PEL is a rapidly progressing malignancy with a median survival time of approximately 6 months even under the conventional chemotherapy [36]

It has been in use for over 20 years and has a large following