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Whilst palpitations during a calorie deficit are often benign and self-limiting, they should not be dismissed without proper assessment, particularly if they are frequent, prolonged, or accompanied by other symptoms

This test is the most direct way to identify the condition

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SAM radiolabeled S-adenosyl-L-[methyl-3H]methionine a radiometric assay was performed by RBC using 1 M-50 pM tolcapone as an inhibitor positive control

A subset of clinical research has also demonstrated that adding B12 (and other B-vitamins) to existing antidepressant regimens can improve response rates compared to antidepressants alone, particularly when baseline B12 was suboptimal