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When the UPR fails to clear misfolded proteins through proteasomal degradation, cells are unable to resolve ER stress, leading to apoptosis and subsequent degradation of TM tissue

Mesotherapy is an effective non-invasive procedure for combating hyperpigmentation

Figure 1B shows the metabolic competition creates a tug-of-war between cancer and immune cells, as they vie for access to the limited glutamine resources [21, 22]

IFD-1 and IFD-2 also act in proteostressed neurons to mediate efficient extrusion of cytoplasmic contents in large exopher vesicles (Summary in Supplementary Fig