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One study noted 17 cytokines had a significant upward linear trend with the severity of ME/CFS: CCL11 (Eotaxin-1), CXCL1 (GRO), CXCL10 (IP-10), IFN (interferon)-y, interleukin (IL)-4, IL-5, IL-7, IL-12p70, IL-13, IL-17F, leptin, G-CSF, GM-CSF, LIF, NGF, SCF, and TGF- (231)

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What this likely means in practice: The first two weeks are primarily about reducing inflammation and initiating repair cascades

2018, In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats, Archives of Toxicology 92:32073221