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Konishi et al., 2008)

Additionally, treatment of DIO mice with the NNMT inhibitor resulted in a substantial ~35% decrease ( P 30% decrease in adipocyte size ( P 40% decrease in adipocyte volume (data not shown) compared to control DIO mice

additionally, low ROS levels in a liver metastatic line was associated with low mitochondrial respiration [7], leading the authors to suggest that ROS production rates parallel mitochondrial activity