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Schmidt, M., Grey, M

*Correspondence: Franziska Weichmann, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Within the realm of bone tissue engineering, this microenvironment comprises both osteogenic and immune cell lineages, including mesenchymal stem cells (MSCs) and pre-osteoblasts as the principal osteogenic cells, and macrophages as the dominant immune cells ( The complexity of the bone defect microenvironment makes cells vulnerable to various factors during regeneration and repair, creating substantial challenges for bone healing and clinical implementation of bone tissue engineering