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Integrated MPS also increased in both legs in LEU (rested: 9%, exercised: 17%), whereas CON improved only the exercised leg (7%)

Although the importance of the potential interaction between IGF-1 signaling and MUSA1, SMART, Nedd4, Trim32, and TRAF6 in skeletal muscle hypertrophy and atrophy remains to be determined, IGF-1 signaling pathway components could be novel targets to regulate these E3 ubiquitin ligase activities in skeletal muscle