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GPX4 is a pivotal regulator of ferroptosis, functioning as a selenoprotein that directly reduces cytotoxic phospholipid hydroperoxides (PLOOH) to benign phospholipid alcohols, thereby preventing lethal lipid peroxidation

Br J Pharmacol 8, 8 (2009)

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Interestingly, astrocytes generated from neural progenitor cells that were isolated from post-mortem tissue from both fALS and sALS patients were similarly toxic specifically to wild-type motor neurons [34]