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The method of injection, which can be either intramuscular (IM) or subcutaneous (SC), determines the appropriate needle gauge and length

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N-demethylation of hydrocodone to form norhydrocodone via CYP3A4 while O-demethylation of hydrocodone to hydromorphone is predominantly catalyzed by CYP2D6 and to a lesser extent by an unknown low affinity CYP enzyme

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