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Other than interfering with brain shape in healthy conditions and resting-state brain function, microbiota also labored to commit numerous CNS diseases such as Alzheimers Disease (AD), depression, and anxiety [72, 73]

Metabolic oxidative stress elicited by the copper(II) complex [cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment

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However, similar to -oxidation in the cytochromes, the peroxisomes generate ROS as they oxidize fatty acids, and likewise, the peroxisomes may induce oxidative stress and promote disease progression [83]

Schutte et al