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99,100 cAMP plays a key role in the functions of many airway cells including controlling ciliary beat frequency (critical for mucus clearance) in airway epithelial cells

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doi:10.1007/s00726-016-2340-y Stefanello FM, Kreutz F, Scherer EBS, Breier AC, Vianna LP, Trindade VMT, Wyse ATS (2007) Reduction of gangliosides, phospholipids and cholesterol content in cerebral cortex of rats caused by chronic hypermethioninemia

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Second, establishing causality between gut microbiome alterations and NIU onset, activity, or prognosis requires longitudinal clinical studies, mechanistic investigations using humanized animal models