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several studies support a causal relationship between augmented NNMT activity in cancer cells and tumor proliferation/progression in a variety of cancerous states with potential implications for NNMT as a biomarker for cancer prognosis and a relevant target for anti-cancer therapeutic development

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[1] [2] This occurs because B12 deficiency commonly affects the peripheral nerves, particularly those extending to the extremities

Folic acid is basically the same as folate, but in a form that can be put in supplements or added to foods

Side effects: Most patients have no significant side effects