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Individuals who have had gastrointestinal surgery, such as weight loss surgery, may also have fewer cells through which to secrete stomach acid and intrinsic factor, inhibiting B12 absorption

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The enzymatic breadth of the JMJDs allows dynamic regulation of both activating and repressive histone codes during cell state transitions

While they offer other potential health benefits, their direct effectiveness as primary weight management tools is not well-documented in clinical research, according to sources like Medical News Today