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Description

The major metabolite in humans and rodents, hydroxy-ITZ (OH-ITZ), is produced by cytochrome P450 (CYP) 3A4

Studies on osteoporosis have confirmed that ferroptosis exacerbates bone loss through its dual effects on osteoblasts and osteoclasts

ALDH2 deficiency did not affect liver disease progression but increased HCC risk in cirrhotic HBV patients with AUD ( Additionally, reduced ALDH2 expression in liver cancer tissues correlates with increased tumor growth, migration, and poor prognosis, and this deficiency disrupts cellular redox balance and metastatic potential ( Accumulation of high levels of HBsAg adds another layer of oncogenic stress by inducing ER stress

Proc Natl Acad Sci 107:97959800 Kaur T, Kumar P, Jamwal S (2018) Protective effect of agomelatine on traumatic brain injury induced cognitive deficit in rats: possible role of neurotransmitters

We found a significant reduction in hippocampal NAA and an increase in mI in RRMS in comparison to age and sex-matched healthy individuals in the cross-sectional analyses