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doi: 10.7554/eLife.54441, 10 AshrafiG.RyanT

2020), as well as in a placebo-controlled, dose-ranging study in 29 PD patients, including subgroups with and without LRRK2 mutation (NCT03710707), according to a press release (Therapeutics 2020)

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Activation of astrocyte MOR elevates cytosolic calcium ions, leading to rapid glutamate release, and further regulating neuronal activity (175, 176)

Studies on glucose metabolism and insulin secretion conducted in p43 knockout mice with preserved expression of other THs receptors have revealed impaired insulin and glucagon secretion by the pancreas, with no effect of glucose on insulin secretion, decreased density of the islets of Langerhans, reduced expression of GLUT2 and Kir 6.2 protein - a subunit of the ATP-dependent K+ channel (32)