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Role of long non-coding RNAs on the regulation of Nrf2 in chronic diseases

Our study constitutes a straightforward but effective approach to inhibit pancreatic cancer via NGF knockdown, suggesting a promising therapeutic direction for pancreatic cancer

Neurotrophic Factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer

First, given the very low expression of target (pHLA) in latently infected cells due to blocks in proviral transcription and translation, we anticipate that a multiple-dose schedule incorporating higher doses will be needed to provide sufficient target occupancy to drive substantial killing of infected cells and thereby achieve the multi-log reductions that are deemed necessary for long-term viral control 61

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