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Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-l is one of the most critical factors controlled by sirtuin activity and is activated through deacetylation by SIRT1

The most common ROS include hydrogen peroxide (H 2 O 2 ), superoxide anion radical (O 2 ), and hydroxyl radical (HO) [37, 38]

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Research indicates preferential accumulation in actively dividing cells and tissues with high metabolic activity, including dermal fibroblasts, keratinocytes, and endothelial cells