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Cascade drug-release strategy for enhanced anticancer therapy

Kirchner 6 and Manhal Izzy 2 , (1)University of Michigan, (2)Vanderbilt University Medical Center, (3)University of Minnesota, (4)Vanderbilt University, (5)Keck Medical Center of USC, Sacramento, CA, (6)Stanford University, Stanford, CA Background: Liver transplantation (LT) is the curative treatment for patients with early unresectable hepatocellular carcinoma (HCC)

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Importantly, the in vitro pretreatment with tazemetostat, a first-class inhibitor of activating enhancer of zeste homolog 2 (EZH2), can upregulate the GD2 expression on GD2 dim MB cells (196)