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Additionally, commenters expressed skepticism that the proposal would increase eCQM reporting since it does not address underlying concerns related to data interoperability and aggregation

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In this study, we screened from an in-house developed metabolites library and identified MeCbl, an endogenous coenzyme form of vitamin B12, as a potent and specific inhibitor of GSDME without any effects on GSDMD

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Conclusion To the authors knowledge, this is the largest study to date examining patient safety and vitamin B12 deficiency