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PLoS ONE 10:e0126978

This methodology presents an issue with linking mechanistic actions of endocrine disrupting chemicals to the risk of disease development since endocrine dysfunction, especially within estrogenic pathways (e.g., menopausal status, menstrual cycle length, early menarche, and contraception use), are typically associated with reasons for hysterectomy (Upson and Missmer, 2020)

Gene-environment interaction studies As described above, various factors, the dual interplay between genetic susceptibility and environmental exposures, defined here as radiation, chemicals, and additional external factors, have become a critical area of research on the lengthy issue of breast cancer origin

PMCID: PMC552978