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To date, a number of senotherapeutics have progressed into clinical phase and tested in those with age-related disorders

The disruption of these interactions results in excessive reactive oxygen species generation, defective steroidogenesis, impaired quality control, and transcriptional dysregulation, ultimately driving oocyte deterioration and follicular failure

Yes, supplements are safe and often necessary

Silencing NRF2 can significantly reduce the expression of SLC7A11 and heme oxygenase-1 (HO-1) and inhibit ferroptosis (69)

16,17,18 Moreover, spatial transcriptomic approaches have begun to preserve tissue context, revealing how aged MuSCs lose positional identity and niche connectivity