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When disulfiram and its active metabolite, sodium diethyldithiocarbamate trihydrate (DDTC) were tested in clinical trials as adjuvant treatments in adults with non-small cell lung cancer and high-risk breast cancer, respectively, both trials demonstrated improvement in overall survival 34,35

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Human data from publicly database analysis The TCGA firehose Legacy datasets on the cBioportal platform (cBioPortal, www.cbioportal.org/) were used to analyze the gene expression of serine metabolism enzymes and TP63 in lung cancer