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10.1186/s13287-015-0103-4 145 ShimizuK.KamadaY.SakamotoA.MatsudaM.NakatsukaM.HiramatsuY

Most of the available evidence is still preclinical, meaning it comes from cell studies, animal models, or specialized delivery-system research rather than large human trials

Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimers, and Parkinsons Diseases

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We can: Not be eating enough B12 Not be making enough gastric acid Not be making intrinsic factor Have a gut thats not healthy and absorbing nutrients adequately Oh and I forgot, you can also be taking medications that can interfere with B12 function and absorption