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101 Phosphorylation of fumarate hydratase (FH) by p38 in response to TGF- signaling leads to its binding to the transcription factor CSL/p53 complex on the p21 promoter, which inhibits histone H3K36 demethylation, enhances p21 transcription, and induces cell growth arrest

Consistent with previous findings (47), the current results demonstrated that all doses of uric acid caused a transient reduction of superoxide anion production in VSMCs at 3 h compared with at the other time points (1, 6, 12 and 24 h)

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Most patients experience the first effects, like improved sleep, within 1 to 2 weeks