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J Neuroinflammation 14:230 Yuan D, Shen J, Yan Y, Wu X, Li A, Guo A, Wu Y, Duan C, Shen J, Tang C et al (2014) Upregulated expression of SSTR1 is involved in neuronal apoptosis and is coupled to the reduction of bcl-2 following intracerebral hemorrhage in adult rats

Auyeung, M

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Mitochondrial dysfunction is associated with depleted levels of NAD + [13] due to the fact that the enzyme nicotinamide mononucleotide adenylyl transferase, which catalyzes the formation of NAD + synthesis from nicotinamide mononucleotide as part of the salvage pathway [482], is dependent on ample supplies of ATP [483,484,485]

Since a characteristic reduction of cerebral perfusion and energy metabolism occurs in patients with AD it is suggested that capillary distortions commonly found in AD brain elicit hemodynamic changes that alter the delivery and transport of essential nutrients, particularly glucose and oxygen to neuronal and glial cells