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In August 2009, the Centers for Medicare and Medicaid Services concluded, "the available evidence does not demonstrate that pharmacogenomic testing of CYP2C9 or VKORC1 alleles to predict warfarin responsiveness improves health outcomes in Medicare beneficiaries." [95] A 2014 meta-analysis showed that using genotype-based dosing did not confer benefit in terms of time within therapeutic range, excessive anticoagulation (as defined by INR greater than 4), or a reduction in either major bleeding or thromboembolic events

The problem with full hGH therapy is that it does a lot of things at once

Fang, S., Niu, Y., Zhang, W., Zhang, Y., Yu, L., Zhang, Y., & Li, X

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It impacts around 20 to 30 people per 100,000 annually in the UK, with roughly 1 in 60 people experiencing it at some point in their lives