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This guide covers its structure, regulation, disease roles and therapeutic targeting

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Similarly, the concomitant downregulation of Adam19, a metalloproteinase closely associated with inflammation and oxidative stress-induced tissue remodeling 56 , further reinforces the hypothesis that APP treatment actively promotes endogenous antioxidant defenses and improves redox homeostasis rather than provoking nonspecific oxidative damage

Moreover, the rupture of the blood vessel wall in hemorrhagic stroke results in the accumulation of hemoglobin and heme iron at the extracellular milieu and subsequent iron-induced LPO and ferroptosis, thereby furtherly exacerbating the stroke-induced brain injury

DIM is a metabolite of indole-3-carbinol (I3C), which is a compound found in cruciferous vegetables such as broccoli, cauliflower, and cabbage