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Finally, we outline translational prospects, arguing that targeting this pathway will require precision medicine strategies, including composite biomarkers and rational combination therapies

Moreover, the neuroinflammation, gut dysbiosis, and associated neuropsychiatric symptoms observed in both conditions may be mitigated through probiotic therapy

MTs are cysteine-rich proteins that regulate Zn and copper homeostasis, are involved in heavy metal detoxification (such as cadmium and mercury), alleviate oxidative/nitrosative stress, and participate in immune responses [331]

Involving a diverse group of participants aged 65 to 79 with or at risk for age-related diseases, the study utilizes a randomized, double-blind, placebo-controlled design to rigorously evaluate metformins geroprotective effects ( 5.1.3 Caloric restriction mimetics CR - as mentioned previously in this review, has long been associated with enhanced longevity and delayed aging across various organisms, primates and mice included (Xie et al., 2022)

3a rather than H-site (ASP101, GLN67, THR68, PRO56, TYR9, GLN54, VAL55, ARG131, ARG45, PHE220) as expected from X-ray data shown in Fig