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Symptoms related to folate deficiency include fatigue, apathy, insomnia, impaired concentration, and irritability ( The folate cycle is crucial for its role in the synthesis of S-adenosylmethionine (SAM) and the metabolism of vitamin B12 (66)

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Other signs include: Pain when raising or moving your arm is a simple shoulder tendonitis test that can signal inflammation Stiffness in the shoulder A shoulder described as tender or with mild swelling A clicking sound in the shoulder Reduced strength and mobility in the shoulder Pain that never fades What can affect the severity of symptoms