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Additional evidence of systemic inflammation effecting the CNS is seen in a mouse model of intraperitoneal LPS injection, which revealed morphological changes in microglia after 3 h, suggestive of an activated state, that persisted up to one week post injection (Yang et al., 2013)

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Transl Gastroenterol Hepatol 6:4 Putcha D, Brickhouse M, Wolk DA, Dickerson BC (2019) Fractionating the rey auditory verbal learning test: distinct roles of large-scale cortical networks in prodromal Alzheimers disease