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Similarly, ablation of IGF-IR in cultured osteoclast precursors reduces the number and size of osteoclasts and their expression of RANK, c-fms, and NFATc1 (unpublished data)

Nonetheless, long-term opioid therapy has a role in the treatment of some patients when used selectively, carefully and combined with an ongoing assessment of risks and benefits

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Discussion In a large nationwide database that includes almost the entire population of Korea, most IPF patients with coexisting CKD did not receive RRT