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Alimentary Pharmacology and Therapeutics 38, 255263

Multiple randomised trials from the 1970s and 1980s have shown its antiparkinsonian efficacy while its antidyskinetic efficacy in PD patients with LIDs was only demonstrated some 30 years after its introduction into PD therapy [13]

Statements Author contributions HD: Methodology, Resources, Writingoriginal draft, Writingreview and editing

An example of an NO prodrug is O 2 -(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K), devised by Keefer et al from the National Cancer Institute

Cold vial + warm water = condensation, which disrupts the stability of the peptide