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[2] Bloomer, R

Circulation Cardiovasc Genet (2010) 3:20714

Exclusion criteria included age under 50 years, lack of consent for data or specimen storage, absence of a study partner, or a diagnosis of moderate to severe Alzheimer's disease or related dementias (Clinical Dementia Rating [CDR] 2)

These results point to a role for autophagy in anabolic signaling beyond the canonical inhibition in response to anabolism, demonstrating that mTORC1 may be unable to operate without contribution from autophagic proteolysis