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This renal IR evidence is directly pertinent to perioperative AKI risk, particularly in settings featuring transient hypoperfusion or clamp-related ischemia ( Sodium nitrite and Sildenafil are being evaluated for their mitochondria-protective effects via enhancing NO signaling and blood flow, which can reduce reperfusion injury (nitrite can inhibit mitochondrial complex I in a reversible manner to reduce ROS burst on reperfusion)

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doi:10.1016/j.jaad.2013.01.032 23Cacoub P, Musette P, Descamps V,

Biomarker Context: When Oxidative Stress Assessment May Be Relevant Not all patients have elevated baseline oxidative stress, and not all benefit from antioxidant supplementation

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