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In particular, increased mitochondrial oxidative stress in fibroblast-derived induced pluripotent stem cells, differentiated into human nigral DA neurons, triggers a DA-dependent toxic cascade, leading to oxidized DA accumulation and reduction in glucocerebrosidase enzymatic activity, lysosomal dysfunctions, and -syn accumulation [49]

Meanwhile, the intrinsic GPx-like activity of ACPP constantly consumes GSH with the assistance of H 2 O 2 and protection of generated ROS to break the antioxidant defense effect of the tumor and further inhibit GPX4 activity, ultimately promoting lipid peroxidation (LPO) accumulation and enhancing the ferroptosis effect

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K., & Rahman, M

This presents significant implications for catheter-mediated enterococcal invasive infection [33]