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While the original series was set in an East Asian fantasy world, the sequelarriving roughly 11 years after the conclusionmoves the setting into the modern day

30 Although it arguably serves as an epidemiologic methods blueprint for future investigations, it is insufficient to justify a wholesale recommendation for a single vaccine formulation with as yet unforeseen consequences on population immunity

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Notably, the depletion of anti-HMGB1 neutralizing antibody or arginine catabolism enzyme (AGRE) mitigates macrophage inflammatory responses, suggesting that restricting HMGB1 expression may be a potential approach for managing macrophage inflammation (103, 104)