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Among these, 50 studies [25 case-control and 25 cohort studies (including registry-based nested case-control studies)] met the study inclusion criteria (Figure 1 and Table 1)

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The negative nicotine effects on collagen synthesis can also lead to slower wound healing and premature wrinkling of the skin

Therefore the development of a standardized approach to evaluate the e-cigarette toxicity is doubtless an urgent need [6]

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