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For example, not drinking several hours before night time may decrease the number of times you need to get up to use the bathroom at night

(2001) IUBMB Life , 52 , 159-164

The relationship between dose, route of administration, and clinical outcomes requires systematic investigation to establish therapeutic ranges and maximize efficacy while minimizing potential risks

In experiments utilizing a BMPR2 gene mutant mouse model, it was discovered that 16-OHE upregulates miRNA-29, leading to reduced PPAR expression, subsequently diminishing the levels of CD36 and Glut4, thereby impairing insulin mobilization and inducing insulin resistance [54, 55]

Application of phytochemicals in pharmaceuticals, in Advances in pharmaceutical biotechnology: recent progress and future applications (Singapore: Springer Nature), 5568