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(D) Heatmap representation of transcriptomic profiles of Mock and MST6-I cells, either untreated or treated with secretome/CM from white or TWAT(Mock) and TWAT(MST6-I) adipocytes, related to fatty acid metabolic processes

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INTRODUCTION Methotrexate (MTX) is a synthetic antimetabolite with many therapeutic indications, mainly anti-inflammatory and immunosuppressant at relatively low doses and antineoplastic at high doses.[ , ] MTX competitively inhibits dihydrofolate reductase, so decreasing tetrahydrofolate level leads to blocks the synthesis of purines, pyrimidines, DNA, ribonucleic acid, thymidylate, and proteins.[ , , ] It is well known that MTX is a hepatotoxic drug, and this leads to limitation of its clinical use

& Bouchelouche, P

Individuals in the Conv group were free of infection-related symptoms at 3 months post-infection, whereas those in the PCC group reported persistent symptoms consistent with WHO criteria in effect during the sample collection period 29