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Exploratory pooled brain metastases analyses from DESTINY-Lung01 and DESTINY-Lung02 presented at European Society for Medical Oncology (ESMO) 2023, demonstrated intracranial (IC) efficacy of T-DXd, with IC-ORR of 50% and 30% and median IC-DoR of 9.5 months and 4.4 months, for 5.4 mg/kg and 6.4 mg/kg Q3W schedules, respectively

Therefore, targeting lncRNAs that regulate ferroptosis may offer novel strategies to enhance chemotherapy responses and overcome drug resistance in NSCLC

Furthermore, the provision in redox power (in the form of NADH or via the malate valve, for nitrate and sulfate reduction), and aspartate (for methionine synthesis) may in principle benefit from photorespiration 27,28

Additionally, ROS can activate the cAMP pathway and its downstream signaling cascade, which is important for sperm capacitation and forward movement [41, 43, 45, 46]

Hu Y, Sparks JA, Malspeis S, et al