This can significantly improve therapeutic efficacy, reduce the risk of drug resistance, and limit nonspecific inflammatory damage ( Organic, inorganic, and organic-inorganic composite nanomaterials are the three types of nanomaterials currently used to treat bacterial pneumonia ( Figure 1 )
The activated FLSs recruit peripheral monocytes/macrophages to synovial tissues by releasing chemokines and inflammatory mediators (48)
Conversely, ferroptosis can feed back into the gut via metabolic products such as ROS through blood to aggravate gut dysbiosis, and then form a self-enhancing ferroptosis-gut dysfunction cycle in OA
Conjugation as a tool in therapeutics: Role of amino acids/peptides-bioactive (including Heterocycles) hybrid molecules in treating infectious diseases
To cope with the elevated oxidative stress they generate, cancer cells enhance their antioxidant capacity, largely through sustained activation of the transcription factor NRF2 often driven by mutations in its negative regulator KEAP1