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Mucositis, Periodontitis & Gut-Oral Axis KPV is particularly relevant for patients with refractory periodontitis, pericoronitis, chemotherapy-induced oral mucositis, or chronic low-grade gingival inflammation unresponsive to conventional scaling

doi: 10.4103/abr.abr_235_20 96

Human data are limited, so its real-world benefits and safety in people are not well established

Therefore, our findings showing that ubiquitylated IL-1, akin to the IL-1 K133A or D129A mutants, is inefficiently cleaved by Caspase-1 raises the interesting possibility that IL-1 K133 ubiquitylation impacts the integrity of the K133:D129 electrostatic interaction to limit caspase-1 processing

Luo M, Xu L, Qian Z, Sun X (2021) Infection-Associated Thymic Atrophy