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In these circumstances the dose of amitriptyline may be reduced or a major tranquilizer such as perphenazine may be administered concurrently

Better yet they showed an increased work output of 35% over the control group

In scleroderma, the immune system attack causes inflammation and triggers the body to make too much collagen as if there were an injury that needs repairing

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Notably, in a second phase III trial (MCI 18619, NCT01492686) in which patients were well defined by strict inclusion criteria, the edaravone group showed a significant improvement in the ALSFRS-R score when compared with the placebo group, suggesting a beneficial effect of edaravone for over 24 weeks [19]