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Article: Why You Can't Take NAD+ Directlyand the Best Precursor to Boost NAD+ Effectively Why You Can't Take NAD+ Directlyand the Best Precursor to Boost NAD+ Effectively Key Takeaways The NAD+ molecule as a supplement is largely ineffective because NAD+ cannot enter cells intact and is unstable in supplement form

2026;6:1004136 DOI: Received: August 17, 2025 Accepted: November 24, 2025 Published: January 04, 2026 Academic Editor: Shile Huang, Louisiana State University Health Science Center, USA Neurodegenerative diseases, including Alzheimers, Parkinsons, Huntingtons, and Amyotrophic Lateral Sclerosis, are characterized by multifactorial pathologies that extend beyond neuronal loss to include neuroinflammation, oxidative stress, mitochondrial dysfunction, and glial dysregulation

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