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IMA Fungus 11(1):10

Importantly, neuronal survival is continuously stimulated by trophic factors that function through specific receptors that are regulated by MEK/ERK and that lead to c-AMP response element binding protein (CREB) activation, a key regulator of several cellular processes (Wang et al., 2003)

Ovatodiolide isolated from anisomeles indica induces cell cycle g2/m arrest and apoptosis via a ros-dependent atm/atr signaling pathways

WinterANBrennerMCPunessenNSnodgrassMByarsCAroraYet al

As Rho GTPases need isoprenylation to properly function, their activity essentially depends on the HMGCR enzyme, thus providing a critical link between the MVA pathway and tumor cell metabolism