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Therefore, radiation tends to induce ROS levels and adaptive antioxidant defense systems, which may lead to radio-resistance (Riley, 1994

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Finally, translating laboratory research findings into clinical applications faces the challenge of the translational gap

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To date, eight different variants, including three frameshift mutations (37.5%), two missense mutations (25.0%), one nonsense mutation (12.5%), one copy number mutation (12.5%), and one six-base in-frame deletion (12.5%), have been reported in China in 10 patients from nine unrelated families (Table 1)