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Eine echte gleichzeitige Kombination beider Substanzen ist unblich, da sich ihre Pigmentierungswege berschneiden und sich Effekte schlecht zuordnen lassen

Using genetic in vivo models, the authors showed that deacetylation of HMGCS2 by sirtuin 3 (SIRT3), which belongs to the deacetylase/ADP-ribosylase family of sirtuins, increases HMGCS2 enzyme activity