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When present in the lysosomal membrane, the NNT homolog could harness the lysosomal proton gradient to synthesize cytoplasmic NADPH and NAD + from NADH and NADP + to potentially restore the cytoplasmic redox ratios in aged cells

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[1]International Diabetes Federation, IDF Diabetes Atlas 2024, IDF, idf.org In 2024, the World Health Organization recognized obesity as a chronic disease

The BBB separates the brain from the systemic circulation, controlling the movement of molecules across the vessel walls (16)