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The published research literature describes GHK-Cu as exerting effects through multiple coordinated mechanisms: stimulation of fibroblast proliferation and migration

2 Methodology A comprehensive literature search was conducted in scientific databases including PubMed, Web of Science, ScienceDirect, Google Scholar, WanfangData, Chinese Pharmacopoeia, and China National Knowledge Infrastructure (CNKI) using keywords such as Astragalus , Astragalus L., Astragalus spp., Astragalus , Astragali radix , and Astragali complanati semend

10.1038/nature19784 Nature 62 HoltmaatA.SvobodaK

It also increased activity of RSK1/2/3 kinase based on the phosphotyrosine array analysis [69]